Researchers Uncover a New Gene Variant That Can Protect Against Heart Disease

A variation that protects against heart illnesses and is typical of the Finnish population was found by the University of Helsinki-led FinnGen genetic investigation. The risk of developing heart disease is about one-fifth lower in carriers of the variation than in the general population. The lower-than-average arterial stiffness of the carriers accounts for the newly discovered variant's protection against coronary heart disease. The affected variant is located in the MFGE8 gene, which makes the lactadherin protein. It is well established that lactadherin has an impact on arterial stiffness. The outcomes demonstrate that the variation interferes with the activity of the lactadherin protein. However, this needs to be confirmed by additional study. Based on a FinnGen dataset with more than 260,000 Finnish biobank sample donors, the findings were published in Communications Biology. The FinnGen research dataset enabled the discov...