Research Shows Salt Substitutes Lower Risk of Heart Attack/Stroke and Death



Dietary salt substitutes reduce the incidence of heart attack, stroke, death from all causes, and cardiovascular disease, according to a pooled data analysis of the current evidence.

Benefits are anticipated to be universal, according to researchers.

Dietary salt substitutes reduce the incidence of heart attack, stroke, death from all causes, and cardiovascular disease, per a pooled data analysis of the current evidence. On August 9, the results were released in the BMJ journal Heart.

The researchers think that individuals all over the world are likely to benefit from these substitutes' positive impacts.

Cardiovascular disease is the largest cause of death worldwide, and high blood pressure is a major risk factor for an early death. Blood pressure is known to rise with a diet that is heavy in sodium and low in potassium.

According to the study, 1.28 billion people worldwide have excessive blood pressure, yet more than half of these cases go untreated.

Blood pressure is known to be lowered by salt substitutes that replace a portion of sodium chloride (NaCl) with potassium chloride (KCl).

Salt replacements reduce the incidence of heart attacks, strokes, and early mortality, according to a sizable study from China that was recently published (Salt Substitute and Stroke Study; SSaSS). It wasn't obvious, though, whether similar advantages would extend to other regions of the world.

The scientists searched through research databases looking for randomized clinical studies that reported on the effects of a salt substitute on blood pressure, cardiovascular health, and early death up until the end of August 2021 in an effort to shed light on this.

The two numbers that make up blood pressure, which is expressed in mm Hg, are the systolic (upper) number, which represents the power with which the heart pumps blood throughout the body, and the diastolic (lower) value, which represents arterial pressure when the heart is filling with blood.

They combined the findings from 21 pertinent international clinical trials with just under 30,000 participants. These were conducted in South-East Asia, the Americas, Western Pacific, and Europe.

From one month to five years were used for the study durations. The salt substitutes' sodium chloride content ranged from 33% to 75%, while their potassium content ranged from 25% to 65%.

All of the individuals' blood pressure was decreased with salt substitutes, according the analysis of the pooled data. Systolic blood pressure decreased generally by 4.61 mm Hg, while diastolic blood pressure decreased overall by 1.61 mm Hg.

No of the location, age, sex, history of high blood pressure, weight (BMI), baseline blood pressure, or baseline sodium and potassium levels in the urine, blood pressure reductions appeared to be consistent across all of these variables.

Additionally, the systolic blood pressure dropped by 1.53 mm Hg and the diastolic blood pressure dropped by 0.95 mm Hg for every 10% less sodium chloride in the salt alternative. There was no evidence that increasing one's potassium intake was bad for one's health.

A pooled data analysis of the findings from five of these trials, which included over 24,000 people, revealed that salt substitutes reduced the risks of cardiovascular disease by 13%, heart attack or stroke by 11%, and early mortality from any cause by 11%.

The researchers recognize that their findings have certain limitations, including the fact that the studies included in the pooled data analysis had different study designs and that there were very limited data for individuals without high blood pressure.

However, they point out that their results concur with those of the SSaSS, the largest-ever study to date of a potassium-enriched salt alternative.

The observed consistent blood pressure reductions "make a strong case for generalisability of the cardiovascular protective effect observed in the SSaSS both outside of China and beyond," the authors write. "Blood pressure lowering is the mechanism by which salt substitutes confer their cardiovascular protection."

These findings support the use of salt substitutes in clinical practice and public health policy as a strategy to reduce dietary sodium intake, increase dietary potassium intake, lower blood pressure, and prevent major cardiovascular events, the researchers write. "These findings are unlikely to reflect the play of chance," they add.

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis, Xuejun Yin, Anthony Rodgers, Adam Perkovic, Liping Huang, Ka-Chun Li, Jie Yu, Yangfeng Wu, J. H. Y. Wu, Matti Marklund, Mark D. Huffman, J. Jaime Miranda, Gian Luca Di Tanna, Darwin Labarthe, Paul Elliott, Maoyi Tian, and Bruce Neal

By BMJ

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