Scienceblogtwo

Antibody proteins are used by the immune system to identify and combat invasive invaders. Researchers are looking into nanobodies, which are little antibodies found in the blood of animals like llamas and sharks, to treat cancer and autoimmune illnesses. Now, researchers from Johns Hopkins Medicine have contributed to the development of a nanobody that can pierce the protective layer that surrounds brain cells and separate misshaped proteins that are the root of conditions like Parkinson's disease, Lewy body dementia, and other neurocognitive issues. The study, which was just published in the journal Nature Communications, was a collaboration between researchers from Johns Hopkins Medicine, working under the guidance of Xiaobo Mao, Ph.D., and researchers from the University of Michigan, Ann Arbor. They sought a new therapeutic approach that might focus on the abnormal proteins known as alpha-synuclein, which have a propensity to aggregate and obstruct the function of brain cells. A...

Parkinson's disease does not yet have any disease-modifying medicines that can change how the disease develops. A team of professionals from all around the world are working to change that under the direction of researchers at the University of Colorado Anschutz Medical Campus. They just released a new study in the journal Brain that advances understanding of the key protein known as -synuclein (Syn), which they discovered links Parkinson's disease and inflammation.                                                                     Neurodegenerative illnesses like Parkinson's disease and Lewy body dementia have been connected to the protein Syn, which is mostly produced in neurons. In this new study, a novel mechanism involving interferon activation and neuronal Syn function is identified as a potential initiator ...

According to a recent study, drinking seven or more alcoholic beverages per week is associated with brain alterations and cognitive deterioration. A recent PLOS Medicine study with over 21,000 participants discovered a link between higher levels of iron in the brain and weekly alcohol use of seven or more units. Iron accumulation in the brain has been linked to Alzheimer's and Parkinson's illnesses and may play a role in the cognitive deterioration brought on by alcohol consumption. There is growing evidence that even moderate alcohol consumption can harm the health of the brain. Alcohol consumption and brain iron levels were examined by Anya Topiwala and colleagues from the University of Oxford in the UK. They used magnetic resonance imaging (MRI) to look at the brains of 20,965 volunteers from the UK Biobank who supplied information on their personal alcohol intake. A total of nearly 7,000 persons had their livers evaluated using MRI in order to detect the levels of systemic ...

Darkness in the Thoughts Concept of Dream Nightmare According to a study, having frequent nightmares may be an early sign of Parkinson's disease. Researchers at the University of Birmingham believe that older persons who start to have nightmares or unsettling dreams may be exhibiting the early signs of Parkinson's disease. Recent research that was published in the journal eClinicalMedicine found that those who frequently experienced nightmares were twice as likely to eventually receive a Parkinson's diagnosis as those who did not. The study involved a cohort of elderly males. The prospect of using nightmares as a risk factor for Parkinson's has not been investigated, despite previous studies showing that persons with Parkinson's disease had more nightmares and unsettling dreams than adults in the general population. "Although it can be incredibly helpful to diagnose Parkinson's disease early, there are very few risk factors, and many of these need expensive...