A new holographic microscope allows scientists to see through the skull and image the brain

A new kind of holographic microscope was created by researchers under the direction of Associate Director CHOI Wonshik of the Center for Molecular Spectroscopy and Dynamics within the Institute for Basic Science, Professor KIM Moonseok of The Catholic University of Korea, and Professor CHOI Myunghwan of Seoul National University. The new microscope reportedly has the ability to "see through" the intact skull and can image the neuronal network in a living mouse brain in high-resolution 3D without removing the skull. * A substantial amount of light energy must be delivered to the sample in order to examine its interior structures using light, and the signal reflected from the target tissue must be precisely measured. It is challenging to produce clear images in live tissues due to the numerous scattering effects and severe aberration1 that frequently happen when light strikes the cells. Light experiences repeated scattering in intricate structures like living tissue, which caus...