Modern humans generate more brain neurons than Neanderthals
Researchers have long been motivated by the query of what distinguishes contemporary humans from earlier species. The Neanderthals, our nearest living ancestors, offer fascinating insights in this regard. The expansion of the brain and the synthesis of new neurons throughout brain development are thought to be key contributors to the evolution of higher cognitive functions in humans. Although modern humans and Neanderthals both have brains of a similar size, little is known about whether the creation of neurons in modern human and Neanderthal brains throughout development may have varied. The protein TKTL1, which differs from the Neanderthal variant only by one amino acid, is now known to increase basal radial glia, a type of brain progenitor cell, in the modern human brain, according to research from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden. The bulk of the neurons in the growing neocortex, an area of the brain essential for many cognitive f...