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Scientists engineer synthetic DNA to study 'architect' genes

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Using innovative synthetic DNA technologies and genomic engineering in stem cells, researchers at New York University have manufactured artificial Hox genes, which regulate and dictate where cells go to develop tissues or organs. Their research, which was published in Science, supports how Hox gene clusters assist cells in learning and remembering their location within the body. An anterior-posterior axis, or a line that extends from the head to the tail, is a feature shared by almost all species, including people, birds, and fish. Hox genes serve as architects during development, laying out the blueprint for where cells will go along the axis and what body parts they will form. Hox genes control where organs and tissues grow, making the thorax or giving wings their proper anatomical placement. Hox genes can malfunction due to dysregulation or mutation, leading to cell loss that can contribute to certain malignancies, birth abnormalities, and miscarriages. According to co-senior author...