More Effective Cancer Immunotherapy: Stanford’s New Method To Find Antigens That Trigger Specific Immune Cells

The surface of a cell can reveal its secrets. It is embellished with tens of thousands to hundreds of thousands of molecules that aid immune cells in differentiating between friends and enemies. Antigens are some of those obtruding substances that cause the immune system to assault. However, it can be challenging for researchers to locate those antigens in the molecular forest since they frequently differ between individuals. A group of Stanford researchers has created a novel technique to predict which antigens will trigger a potent immune response more quickly and correctly. Their method might aid in the development of more potent cancer immunotherapies. The research, which was directed by Polly Fordyce, an Institute Scholar at Sarafan ChEM-H, will be published in the journal Nature Methods today, September 5, 2022. Immune cells known as T cells prowl the body, squeezing past other cells as they go. They employ T cell receptors to read peptides, or brief proteins, that are molecularl...