Daily Multivitamin May Slow Cognitive Aging for Older Adults



"Effects of cocoa extract plus a multivitamin on cognitive function: a randomized clinical trial" will appear in the Journal of the Alzheimer's Association. The three-year research of more than 2,200 older persons found a statistically significant cognitive improvement from daily multivitamin-mineral intake. Global cognition was found to be unaffected by cocoa extract.

"This is the first conclusive, extensive, long-term study to suggest that older persons who use multivitamin-mineral supplements may delay cognitive aging. Although the Alzheimer's Association finds these findings encouraging, we are not yet prepared to advise the broad use of a multivitamin supplement to lower the risk of cognitive decline in older persons, according to Maria C. Carrillo, Ph.D., the Alzheimer's Association's chief science officer.

"Larger, more varied study populations require independent confirmatory studies. Future therapies and preventative measures must be successful across all demographics, according to Carrillo. People should discuss the advantages and hazards of all dietary supplements, including multivitamins, with their health care providers for the time being and until further data is available.

Carrillo continues to have hope for the development of new dementia and cognitive aging therapies. "We envision a future where multiple therapies and risk reduction strategies that address cognitive aging and dementia in multiple ways are available, similar to how they address heart disease and cancer, and that can be combined to create potent combination therapies... in addition to brain-healthy guidelines for lifestyle factors like diet and exercise," the authors write.

Alzheimer's & Dementia, September 14, 2022, "Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial."

An investigator-initiated grant from Mars Edge, a division of Mars focused on nutrition research and products, is helping to fund the COcoa Supplement and Multivitamin Outcomes Study (COSMOS). This award covered infrastructure costs as well as the contribution of study tablets and packaging. Haleon offered assistance by providing some study pills and packing. Additionally, funding from the National Institutes of Health, Bethesda, Maryland, number AG050657, AG071611, EY025623, and HL157665 help to support COSMOS. Through contracts 75N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, and 75N92021D00005, the National Heart, Lung, and Blood Institute, National Institutes of Health, and U.S. Department of Health and Human Services fund the Women's Health Initiative (WHI) program. Mars Edge and Haleon made no contributions to the development of the manuscript, the interpretation of the results, or the data analysis.                                                                                                                                                                      By ALZHEIMER’S ASSOCIATION 

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